TABLE 1.

Classification of HLA-superalleles in to SF and SU on the basis of mean OS difference.

HLA superalleles	#No. of Samples		#Mean OS		Mean Diff OS (P-A)	P-value	Risk status
	Present (P)	Absent (A)	Present (P)	Absent (A)
HLA-B*55	16	385	94.58	58.46	36.12	0.002
HLA-DPB1*01	34	367	87.51	57.34	30.17	6.82E-07
HLA-B*08	80	321	81.09	54.62	26.47	6.36E-14
HLA-DRB1*03	85	316	80.14	54.46	25.69	2.29E-14
HLA-B*49	11	390	77.87	59.39	18.48	0.037
HLA-A*01	115	286	72.88	54.68	18.2	1.24E-17
HLA-C*05	61	340	72.74	57.6	15.15	1.82E-12
HLA-DPB1*10	16	385	72.87	59.36	13.51	0.0004
HLA-C*07	217	184	66.01	52.7	13.31	3.65E-31
HLA-B*14	27	374	48.34	60.74	–12.39	2.20E-05
HLA-A*24	81	320	48.59	62.77	–14.18	5.61E-13
HLA-DPB1*05	17	384	46.26	60.51	–14.25	0.001
HLA-A*31	26	375	46.34	60.84	–14.5	1.76E-05
HLA-DPB1*11	10	391	45.32	60.27	–14.95	0.003
HLA-DRB1*07	103	298	48.37	63.89	–15.51	4.31E-14
HLA-DPB1*06	12	389	43.68	60.4	–16.72	0.014
HLA-C*14	10	391	43.44	60.32	–16.88	0.003
HLA-B*18	39	362	44.41	61.57	–17.16	1.07E-08
HLA-C*01	42	359	44.35	61.72	–17.37	9.08E-07
HLA-B*13	19	382	41.94	60.79	–18.86	0.03
HLA-A*30	26	375	42.14	61.13	–19	5.22E-06
HLA-DRB1*16	23	378	29.53	61.75	–32.22	7.00E-06
HLA-B*50	12	389	25.03	60.98	–35.95	6.33E-05
HLA-DRB1*12	19	382	23.46	61.71	–38.26	9.43E-05

#Samples (P): No of SKCM-patients in which HLA-superallele is present; # Samples (A): No of SKCM-patients in which HLA-superallele is absent; #Mean OS (P): Average OS in which HLA-superallele is present; # Mean OS (A): Average OS in which HLA-superallele is absent; Mean Diff OS: Mean difference in mean OS between patients with a specific HLA typing and patients without it; Risk status Survival Favorable (SF) or Survival Unfavorable (SU) HLA-superallele, SF considered as low-risk and SU taken as high-risk groups.