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. 2020 Mar 21;32:101514. doi: 10.1016/j.redox.2020.101514

Fig. 4.

Fig. 4

Exogenous spermine up-regulates the expression of cytomembrane CaSR in cardiomyocytes by inhibiting ER stress. GSK2606414, STF-083010, AEBSF HCI, and 4-PBA were used to inhibit the ER stress. (a) The representative bands and quantification statistics of PERK signaling pathway, (b) The representative bands and quantification statistics of IRE1 signaling pathway, (c) The representative bands and quantification statistics of ATF6 signaling pathway, (d) The representative bands and quantification statistics of Grp78, Grp9, CHOP and cytomembrane CaSR protein expression, (e) The expression of CaSR in ER-cytoplasm-cytomembrane was detected by Western blot. **, P < 0.01 versus Control group; ***, P < 0.001 versus Control group; #, P < 0.05 versus HG group; ##, P < 0.01 versus HG group; ###, P < 0.001 versus HG group.