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. 2020 Mar 26;52(1):1–18. doi: 10.3947/ic.2020.52.1.1

Table 2. Prognostic biomarkers of sepsis.

Category Biomarker Ability to predict Patients Variables AUC 95% CI Ref
Soluble receptors suPAR 28-day mortality Sepsis [95] (n = 130) suPAR 0.77 0.68 – 0.86 [98]
Lactate 0.70 0.59 – 0.80
CC chemokine ligand 2 MCP-1 30-day mortality Sepsis [1] (n = 136) MCP-1 0.64 0.55 – 0.74 [99]
PCT 0.57 0.47 – 0.68
CRP 0.51 0.40 – 0.62
IL-6 0.69 0.59 – 0.78
SOFA 0.67 0.57 – 0.77
qSOFA 0.63 0.48 – 0.78
APACHE II 0.74 0.65 – 0.83
Acute phase protein PTX-3 28-day mortality Sepsis [1] (n = 83) PTX-3 0.82 0.68 – 0.96 [100]
PCT 0.64 0.50 – 0.77
CRP 0.56 0.40 – 0.73
APACHE II 0.77 0.59 – 0.94
SOFA 0.59 0.40 – 0.79
MR-proADM 28-day mortality Sepsis [1] (n = 326) MR-proADM 0.79 0.74 – 0.84 [59]
Lactate 0.71 0.64 – 0.77
PCT 0.61 0.55 – 0.68
CRP 0.54 0.47 – 0.61
SOFA 0.75 0.69 – 0.80
ADM 30-day mortality Sepsis [1] (n = 215) Bio-ADM 0.827 0.770 – 0.875 [64]
SOFA 0.830 0.774 – 0.878
Angiogenic growth factor Angiopoietin 28-day mortality Sepsis [1] (n = 145) Angpt-2/1 0.736 0.649 – 0.823 [90]
SOFA 0.745 0.655 – 0.836
28-day mortality Sepsis [95] (n = 333), control (n = 55) Angpt-2/1 0.845 0.810 – 0.880 [91]
PCT 0.732 0.685 – 0.780
MEDS score 0.826 0.785 – 0.866
Non-coding RNAs miRNA 28-day mortality Sepsis [93] (n = 214) miR-223 0.748 P <0.001 [71]
miR-15a 0.610 P = 0.015
miR-16 0.760 P <0.001
miR-122 0.744 P <0.001
miR-193b 0.790 P <0.001
miR-483-5p 0.657 P <0.001
Lnc-NEAT1 28-day mortality Sepsis [93] (n = 82), healthy (n = 82) Lnc-NEAT1 0.726 0.615 – 0.837 [79]
miR-124 miR-124 0.784 0.668 – 0.900
Lnc-NEAT1/miR-124 axis 0.830 0.738 – 0.922
Lnc-MALAT1 Mortality Sepsis [1] (n = 120), healthy controls (n = 60) Lnc-MALAT1 0.886 0.819 – 0.954 [83]
Lactate 0.868 0.800 – 0.937
SOFA 0.943 0.905 – 0.981
APACHE II 0.856 0.802 – 0.934
Lnc-MEG3 28-day mortality Sepsis [1] (n = 219), healthy (n = 219) Lnc-MEG3 0.704 0.626 – 0.783 [84]
APACHE II 0.793 0.729 – 0.857
SOFA 0.758 0.687 – 0.830

AUC, area under the curve; CI, confidence interval; Ref, reference; suPAR, soluble urokinase plasminogen activator receptor; MCP-1, monocyte chemoattractant protein 1; PCT, procalcitonin; CRP, C-reactive protein; IL, interleukin; SOFA, sequential organ failure assessment; APACHE II, acute physiology and chronic health evaluation II; PTX-3, pentraxin-3; MR-proADM, mid-regional fragment of pro-adrenomedullin; ADM, adrenomedullin; Angpt, angiopoietin; MEDS, mortality in emergency department sepsis; NEAT, nuclear enriched abundant transcript; MALAT, metastasis-associated lung adenocarcinoma transcript; MEG, maternally expressed gene.