Table 2.
Peripheral markers in sarcopenic vs. non‐sarcopenic participants
| Biomarker | EWGSOP Sarcopenia (Janssen) | EWGSOP No sarcopenia (Janssen) | EWGSOP Sarcopenia (Masanés) | EWGSOP No sarcopenia (Masanés) |
EWGSOP2 probable sarcopenia |
EWGSOP2 no sarcopenia |
|---|---|---|---|---|---|---|
| IFNγ (pg/ml) | 7.8 ± 6.7 | 10.0 ± 14.8 | 9.9 ± 21.4 | 9.8 ± 8.8 | 9.9 ± 14.5 | 6.9 ± 5.7 |
| IL‐1β (pg/ml) | 1.0 ± 0.7 | 1.4 ± 1.5 | 1.0 ± 0.8 | 1.5 ± 1.7 | 1.4 ± 1.5 | 0.8 ± 0.6 |
| IL‐6 (pg/ml) | 15.3 ± 12.7 | 12.2 ± 10.3 | 12.3 ± 12.9 | 12.8 ± 9.3 | 12.6 ± 10.9 | 10.8 ± 5.5 |
| TNFα (pg/ml) | 7.9 ± 6.2 | 8.3 ± 5.8 | 6.8 ± 4.7 | 9.1 ± 6.2 | 8.2 ± 5.9 | 8.7 ± 4.4 |
| 20S (nmol AMC/mg protein) | 13.1 ± 3.7 | 13.3 ± 5.0 | 12.9 ± 4.0 | 13.6 ± 5.2 | 13.2 ± 4.9 | 14.2 ± 4.9 |
| nmol GSH/mg protein | 48.4 ± 34.4 | 53.0 ± 25.4 | 51.8 ± 30.1 | 53.4 ± 24.5 | 53.1 ± 26.7 | 44 ± 21 |
| nmoles GSSG/mg protein | 2.1 ± 0.9 | 2.6 ± 1.5 | 2.6 ± 1.3 | 2.6 ± 1.6 | 2.6 ± 1.5 | 1.9 ± 1.1 |
| GSH/GSSG | 22.8 ± 9.3 | 25.7 ± 17.8 | 22.5 ± 12.3 | 27.0 ± 19.1 | 25 ± 16.9 | 29.3 ± 19.2 |
| CAT activity (IU/min.mg protein) | 2904.1 ± 1428.7 | 3328.5 ± 1482 | 3037.2 ± 1429.6 | 3431 ± 1498 | 3267.3 ± 1500.9 | 3433.8 ± 1045.6 |
| SOD activity (U/mg protein) | 14.7 ± 8.5 | 15.1 ± 10.8 | 13.8 ± 9.6 | 15.6 ± 11.0 | 14.8 ± 10.1 | 20.6 ± 15.5 |
| GPx activity (nM NADPH/min.mg protein) | 82.3 ± 37.5 | 104.5 ± 81.9 | 97.5 ± 81.4 | 104.8 ± 77.6 | 102.1 ± 79.3 | 107 ± 65.5 |
| BuChE activity (U/mg protein) | 2.1 ± 0.9 | 2.4 ± 1.0 | 2.5 ± 0.9 | 2.4 ± 1.0 | 2.4 ±0.9 | 2.7 ±1.7 |
| CAF (pM) | 536.1 ± 1054.1 | 440.6 ± 632.4 | 439.2 ± 681.2 | 493.0 ± 768.2 | 456.4 ± 727.3 | 378.7 ± 229.2 |
IFNγ: interferon gamma. IL: interleukin. TNFα: tumor necrosis factor alpha. 20S: 20S proteasome. GSH: glutathione reduced form. GSSG: glutathione oxidized form. GSH/GSSG: glutathione redox ratio. CAT: catalase. SOD: superoxide dismutase. GPx: glutathione peroxidase. NADPH: Nicotinamide adenine dinucleotide phosphate reduced. BuChE: butyrylcholinesterase. CAF: C‐terminal agrin fragment. EWGSOP: European working group on sarcopenia in older people. In bold: significant results (p < 0.05).