Figure 4.

Effect of glucocorticosteroid treatment on COL1A1, MDH2 and ANKRD2. (A) Result of the test on differences between the three treatment groups. The plot compares the expected −log₁₀p‐values when the null hypothesis is true (x‐axis) to the −log₁₀p‐values obtained from the test. COL1A1, MDH2, and ANKRD2 are significant at 5% level after FDR correction for multiple testing. (B) Overlap between the lists of proteins significantly associated with age, loss of ambulation, and treatment. (C) Comparison of the effect sizes of prednisone and deflazacort across proteins. It can be observed that prednisone and deflazacort tend to have similar effects on several proteins (Pearson's correlation coefficient = 0.795). The points corresponding to COL1A1, MDH2, and ANKRD2 are highlighted in red. (D) Boxplots comparing protein expression levels across treatment groups for each of the significant proteins. Points denoting individual measurements are plotted using colours to distinguish hospital and shape to distinguish between samples from ambulant and from non‐ambulant patients.