Table 5.
Significance of the association between protein levels and time to loss of ambulation, after correction for age
| Protein | Antibody | P‐value | FDR |
|---|---|---|---|
| KRT10 | HPA012014 | 0.0018 | 0.0388 |
| MDH2 | HPA019848 | 0.0026 | 0.0388 |
| DES | HPA018803 | 0.0076 | 0.0758 |
| MYL3 | HPA016564 | 0.0139 | 0.1044 |
| CK | HPA001254 | 0.0221 | 0.1204 |
| COL1A1 | HPA011795 | 0.0261 | 0.1204 |
| ETFA | HPA018990 | 0.0281 | 0.1204 |
| C4BPA | HPA000926 | 0.0375 | 0.132 |
| LCP1 | HPA019493 | 0.0396 | 0.132 |
| TNNT2 | HPA015774 | 0.099 | 0.2736 |
| PDZK1 | HPA005755 | 0.1088 | 0.2736 |
| MYOM3 | HPA029752 | 0.1198 | 0.2736 |
| RELB | HPA011985 | 0.1276 | 0.2736 |
| AKAP1 | HPA008691 | 0.1277 | 0.2736 |
| NES | HPA026111 | 0.1594 | 0.3188 |
| ANKRD2 | HPA040884 | 0.1975 | 0.3703 |
| LDHB | HPA019007 | 0.2373 | 0.4162 |
| TNNT3 | HPA037810 | 0.259 | 0.4162 |
| TTN | HPA007042 | 0.2636 | 0.4162 |
| HDAC2 | HPA011727 | 0.3182 | 0.4651 |
| GSN | HPA070538 | 0.3424 | 0.4651 |
| BASP1 | HPA050333 | 0.3428 | 0.4651 |
| C3 | HPA003563 | 0.3599 | 0.4651 |
| CFH | HPA049176 | 0.3721 | 0.4651 |
| C4A | HPA048287 | 0.4092 | 0.4765 |
| MGP | HPA014274 | 0.4267 | 0.4765 |
| MAP 4 | HPA038150 | 0.4289 | 0.4765 |
| FH | HPA027341 | 0.4797 | 0.4926 |
| CA3 | HPA021775 | 0.4864 | 0.4926 |
| ENO3 | HPA000793 | 0.4926 | 0.4926 |
Results of the test on the significance of each antibody in a Cox model where we controlled for baseline age. P‐value is the P‐value of the Wald test on the significance of the antibody (main effect + interaction with baseline age), and FDR is the P‐value after application of the Benjamini–Hochberg multiple testing correction.