Body composition evaluation of SAMP8 mice by dual energy X‐ray absorptiometry (DXA). (A) Percentage lean mass and (B) percentage fat mass of SAMP8 mice in different groups at 1, 2, and 3 months. Percentage lean mass in CTL group was lower than HMB, VIB, and COM groups at month 2 post‐intervention, while the percentage fat mass in CTL group was higher than HMB, VIB, and COM groups at month 2. (C) Representative image of whole‐body DXA scanning (lean mass mode) (D) and (fat mass mode) demonstrating that the HMB, VIB, and COM groups showed higher percentage lean mass and lower fat mass at month 2, respectively. Lean and fat masses indicated by white arrows. *P < 0.05; **P < 0.01. (E) Serum myostatin level of COM group showed significantly higher than CTL group at month 3. (F) Serum adiponectin level of VIB group showed significantly higher than CTL group at month 3. *P < 0.05. HMB, β‐hydroxy‐β‐methylbutyrate; SAM, senescence‐accelerated mouse.