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RANKL/osteoprotegerin interaction at the level of the bone. The essential signalling pathway for normal osteoclastogenesis. Under physiologic conditions, RANKL produced by osteoblasts binds to RANK on the surface of osteoclast precursors, triggering the transcription of osteoclastogenic genes. OPG inhibits the initiation of the process by binding to RANKL. OPG, osteoprotegerin; RANKL, receptor activator of nuclear factor‐κB ligand.
