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. 2020 Apr 1;5(2):e00146-20. doi: 10.1128/mSphere.00146-20

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Copyright © 2020 Kiefer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — Zinc inhibits ST-mediated induction of cGMP in T84 epithelia. (A) Zinc (0.1 mM to 2.0 mM) was added to T84 cells 1 h prior to ST treatment with zardaverine (20 μM) and vardenafil (50 μM). At high zinc concentrations, ST-mediated induction of cGMP was significantly decreased. (B) In vitro reconstituted zinc-ST failed to induce cGMP accumulation in T84 epithelia compared to that with STh. Values are means ± standard deviations versus ST alone. *, P < 0.05; ***, P < 0.0005; Untx, untreated; Ø, no zinc added.