FIGURE 1.

Non-selective mitophagy. Mitophagy shares the core molecular machinery with general macroautophagy and can occur in a non-selective fashion. Thus, mitochondria are engulfed during the nucleation and elongation phase into the forming phagophore together with other cellular content such as protein aggregates, endoplasmic reticulum (ER) derived structures and invasive bacteria. The fusion of the phagosome with lysosomes leads to the formation of the autophagolysosome and the degradation of its content.