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. 2020 Mar 26;8:200. doi: 10.3389/fcell.2020.00200

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Copyright © 2020 Chen, Kroemer and Kepp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of Mitophagy on age-related pathologies. Mitophagy is a key mechanism for mitochondrial quality and quantity control. Thus, mitophagy limits the production of reactive oxygen species (ROS), the accumulation of mutations in and the release of mitochondrial DNA (mtDNA), appearance of transmembrane potential loss and the decrease in ATP production. Taken together, mitophagy controls various factors that can drive pathologies such as aging-related disorders and neurodegeneration, cardiovascular disease and cancer.