Table 2.
Top 10 TFs derived from the ChEA3 enrichment analysis. TFs are ranked by an integrated composite score computed based on the individual library ranks.
| Final Rank | Transcription Factor | Biological Role1 | Individual Library Ranks |
|---|---|---|---|
| 1 | CREB3L2 | Cell Proliferation | ARCHS4 Coexpression,30;Enrichr Queries,19;GTEx Coexpression,2 |
| 2 | TWIST2 | EMT, Migration, Invasion | ARCHS4 Coexpression,21;GTEx Coexpression,14 |
| 3 | ELK3 | Invasion, Migration, Angiogenesis | Literature ChIP-seq,9;ARCHS4 Coexpression,43;Enrichr Queries,1;GTEx Coexpression,23 |
| 4 | ZNF469 | ECM | ARCHS4 Coexpression,7;GTEx Coexpression,32 |
| 5 | NR2F2 | Tumor Growth, Metastasis, Tumor Microenvironment | ARCHS4 Coexpression,20; ENCODE ChIP-seq,20; Enrichr Queries,5; ReMap ChIP-seq,47; GTEx Coexpression,8 |
| 6 | GLIS2 | EMT, Inflammation | ARCHS4 Coexpression,40;Enrichr Queries,10;GTEx Coexpression,13 |
| 7 | HIC1 | DNA-damage, Invasion, Metastasis | ARCHS4 Coexpression,24;Enrichr Queries,42;GTEx Coexpression,1 |
| 8 | NFATC4 | Cell Cycle and Apoptosis, Inflammation | ARCHS4 Coexpression,35;Enrichr Queries,27;GTEx Coexpression,19 |
| 9 | NPAS2 | Cell Survival, Cell Growth, DNA-damage | ARCHS4 Coexpression,28;Enrichr Queries,17;GTEx Coexpression,39 |
| 10 | TWIST1 | EMT, Angiogenesis, Invasion, Metastasis | ARCHS4 Coexpression,37;Enrichr Queries,53;ReMap ChIP-seq,19;GTEx Coexpression,7 |
1
Literature available in Supplementary File S2.