Table 4.
Pathways and GO associated with the 15 gene features in PreMSIm.
| Gene Symbol | Pathway | GO (BP) |
|---|---|---|
| DDX27 | NA | ribosome biogenesis; rRNA processing |
| EPM2AIP1 | NA | positive regulation of glycogen biosynthetic process |
| HENMT1 | Gene Expression; Mitotic Prophase; PIWI-interacting RNA (piRNA) biogenesis | RNA methylation; methylation; gene silencing by RNA; piRNA metabolic process; production of siRNA involved in RNA interference |
| LYG1 | NA | metabolic process |
| MLH1 | Mismatch repair; Gene Expression; Meiosis; DNA Damage; Fanconi anemia pathway; Pathways in cancer; Cell Cycle, Mitotic; DNA Double-Strand Break Repair; Regulation of TP53 Activity; DNA damage_Role of Brca1 and Brca2 in DNA repair; Direct p53 effectors | mismatch repair; DNA repair; cellular response to DNA damage stimulus; cell cycle; double-strand break repair via nonhomologous end joining; reciprocal meiotic recombination; somatic hypermutation of immunoglobulin genes; somatic recombination of immunoglobulin gene segments; meiotic chromosome segregation; homologous chromosome segregation; negative regulation of mitotic recombination; meiotic cell cycle |
| MSH4 | Meiosis; Cell Cycle, Mitotic | meiotic cell cycle; reciprocal meiotic recombination |
| NHLRC1 | Glucose metabolism; Ubiquitin mediated proteolysis; Metabolism | protein ubiquitination; autophagy; glycogen biosynthetic process; regulation of protein phosphorylation; glycogen metabolic process; regulation of gene expression; regulation of protein ubiquitination; response to endoplasmic reticulum stress; cellular macromolecule metabolic process; regulation of protein kinase activity; regulation of protein localization to plasma membrane |
| NOL4L | NA | NA |
| RNLS | NA | oxidation–reduction process |
| RPL22L1 | Gene Expression; Metabolism; Metabolism of proteins | cytoplasmic translation |
| RTF2 | NA | mitotic DNA replication termination; regulation of DNA stability; site-specific DNA replication termination at RTS1 barrier |
| SHROOM4 | NA | multicellular organism development; actin filament organization; actin cytoskeleton organization |
| SMAP1 | Endocytosis | positive regulation of GTPase activity; regulation of clathrin-dependent endocytosis |
| TTC30A | Organelle biogenesis and maintenance | cell projection organization |
| ZSWIM3 | NA | NA |