Fig. 3.
Crystal structure of the papain-like protease domain 1 (PL1pro) of TGEV. Cartoon view of the overall structure (PDB entry: 3MP2; Wojdyla et al., 2010). The thumb, fingers, and palm subdomains are shown in blue, brown, and green, respectively. The Cα atoms of the catalytic triad residues (Cys32−His183−Asp196) are displayed as yellow, blue, and red spheres. Residue Gln27 contributing to the oxyanion hole is shown in ball & stick style. Ile155, Thr209, and Tyr175 forming the S4 pocket are labeled; Ile155 is in black and the latter two are in red. The N and C termini of the PL1pro are indicated.