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. 2017 Nov 8;149:58–74. doi: 10.1016/j.antiviral.2017.11.001

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Fig. 7 — Recently described inhibitors of the CoV PL2^pro. (A) Structural formula of the purine derivative 8-(trifluoromethyl)-9H-purin-6-amine (compound 4). This compound is a competitive MERS-CoV PL2^pro inhibitor (Lee et al., 2015). It is also active against SARS-CoV PL2^pro but acts as an allosteric inhibitor in this case. (B) A natural-product chalcone, compound 6 from the perennial plant Angelica keiskei, inhibits the SARS-CoV M^pro (3CL^pro) and PL2^proin vitro (Park et al., 2016).