Table 2.

Cleavage sites of PL1^pro and PL2^pro in CoVs and the P5-P2′ residues for each cleavage site.

	Nsp1↓2	Nsp2↓3	Nsp3↓4	Reference
TGEV	RTGRG↓AI	NKMGG↓GD	PKSGS↓GF	Putics et al. (2006)
	n. d.	PL1pro	n. d.
HCoV NL63	GHGAG↓SV	TKLAG↓GK	AKQGA↓GF	Chen et al. (2007)
	PL1pro	PL2pro	PL2pro
HCoV 229E	KRGGG↓NV	TKAAG↓GK	AKQGA↓GD	Ziebuhr et al. (2007)
	PL1pro > PL2pro	PL1pro < PL2pro	n. d.
MHV	KGYRG↓VK	RFPCA↓GK	SLKGG↓AV	Bonilla et al. (1997)
	PL1pro	PL1pro	PL2pro	Kanjanahaluethai and Baker (2000)
SARS-CoV#1	ELNGG↓AV	RLKGG↓AP	SLKGG↓KI	Harcourt et al. (2004)
	PL2pro	PL2pro	PL2pro
MERS-CoV#1	KLIGG↓DV	RLKGG↓AP	KIVGG↓AP	Yang et al. (2014)
	PL2pro	PL2pro	PL2pro
IBV#2	/	VCKAG↓GK	EKKAG↓GI	Lim et al. (2000)
	/	PL2pro	PL2pro

↓: cleavage site; n. d., not determined; ^#1: absence of PL1^pro; ^#2: partial presence of PL1^pro; /: absence of the cleavage site.