Table 1.
Highly pathogenic RNA viruses which encode proteins that adopt the Hide, Mask and Hit strategies to block dsRNA recognition.
| Family | Virus | Viral IFN-antagonist involved in targeting the RLRs pathway |
||
|---|---|---|---|---|
| Hide | Mask | Hit | ||
| Arenaviridae (OW) | LASFV | NP | NP, Z | |
| Arenaviridae (NW) | JUNV | NP, Z | ||
| MACV | NP, Z | |||
| Bunyaviridae | CCHFV | L (?) | vOTU | |
| HTNV | L (?) | Gn | ||
| RVFV | NSs | |||
| Coronaviridae | SARS-CoV | nsp4, N | nsp14 | ORF3b, ORF6, M, nsp3 |
| Filoviridae | EBOV | VP35 | VP35 | |
| MARV | VP35 | VP35 | ||
| Flaviviridae | DENV | NS4A | NS3B2 | |
| WNV | NS4A | NS3B2 | ||
| Henipaviridae | HeV | V, W | ||
| NiV | V, W | |||
| Orthomyxoviridae | IAVs | NS1 | NS1, PB1, PB2, PA, PB1-F2 | |
CCHFV, Crimean-Congo hemorrhagic fever virus; DENV, dengue virus; EBOV, Ebola virus; HTNV, Hantaan virus; HeV, Hendra virus; IAVs, influenza A viruses; JUNV, Junin virus; LASFV, Lassa fever virus; MACV, Machupo virus; MARV, Marburg virus; NiV, Nipah virus; RVFV, Rift Valley fever virus; SARS-CoV, severe acute respiratory syndrome coronavirus; WNV, West Nile virus.