Table 2.
Comparison of Respanel against Resplex I & II with 34 respiratory samples.
| Organism | TP | FP | TN | FN | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) |
|---|---|---|---|---|---|---|---|---|---|
| Adenovirus | 1 | 0 | 31 | 2 | 33 | 100 | 100 | 94 | 94 |
| Human Metapneumovirus | 1 | 0 | 33 | 0 | 100 | 100 | 100 | 100 | 100 |
| Influenza A | 2 | 6 | 26 | 0 | 100 | 81 | 25 | 100 | 82 |
| Influenza B | 0 | 0 | 34 | 0 | – | 100 | – | 100 | 100 |
| Parainfluenza Virus 1 | 1 | 0 | 33 | 0 | 100 | 100 | 100 | 100 | 100 |
| Parainfluenza Virus 2 | 2 | 1 | 31 | 0 | 100 | 97 | 67 | 100 | 97 |
| Parainfluenza Virus 3 | 0 | 3 | 31 | 0 | – | 91 | 0 | 100 | 91 |
| Respiratory Syncytial Virus | 3 | 1 | 30 | 0 | 100 | 97 | 75 | 100 | 97 |
| aEnterovirus/Rhinovirus | 12 | 6 | 15 | 1 | 92 | 71 | 67 | 94 | 79 |
| Bocavirus | 6 | 2 | 26 | 0 | 100 | 93 | 75 | 100 | 94 |
| Coronavirus 229E | 0 | 0 | 34 | 0 | – | 100 | – | 100 | 100 |
| Coronavirus OC43 | 2 | 0 | 32 | 0 | 100 | 100 | 100 | 100 | 100 |
| Coronavirus NL63 | 1 | 1 | 32 | 0 | 100 | 97 | 50 | 100 | 97 |
| Coronavirus HKU1 | 0 | 0 | 34 | 0 | – | 100 | – | 100 | 100 |
| Mycoplasma pneumoniae | 4 | 1 | 29 | 0 | 100 | 97 | 80 | 100 | 97 |
| Streptococcus pneumoniae | 10 | 5 | 19 | 0 | 100 | 79 | 67 | 100 | 85 |
| Chlamydophila pneumoniae | 0 | 1 | 33 | 0 | – | 97 | 0 | 100 | 97 |
TP = True positive, FP = False positive, TN = True negative, FN = False negative, PPV = Positive predictive value, NPV = Negative predictive value. Sensitivity, specificity, PPV, NPV and accuracy were calculated as defined in the materials and methods (Section 2.6).
Enterovirus and Rhinovirus results were compared together because Resplex Enterovirus and Rhinovirus assays were reported in aggregate.