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. 2020 Jan 16;48(1):0300060519898336. doi: 10.1177/0300060519898336

Table 1.

Basic characteristics of the included studies.

Study ID Sex(M/F) Meanage N(E/C) TNMstage EST(m) KPS score CHI + chemotherapy regimen Chemotherapy regimen Treatment(days) Outcomes
Chen X 2006 41/19 57.4 30/30 NR NR >70 AD 50 mL + 5-FU 500–750 mg/m2+ DDP 50 mg/m2 5-FU 500–750 mg/m2 + DDP 50 mg/m2 21 days × 2 ①②③
Sun J 2013 59/47 63 53/53 NR ≥3 ≥60 AD 60–100 mL + PTX 150 mg/m2 + DDP 20 mg/m2 PTX 150 mg/m2 + DDP 20 mg/m2 14 days × 2 ③
Yan HX 2013 39/22 61.9 30/31 II–IV NR >70 AD 100 mL + DDP 20 mg/m2 + 5-FU 750 mg/m2 DDP 20 mg/m2 + 5-FU 750 mg/m2 10 days ①②③
Huang XY 2014 26/20 60.5 24/22 III–IV >3 ≥60 AD 50 mL + DDP 30 mg/m2 + 5-FU 500 mg/m2 DDP 30 mg/m2 + 5-FU 500 mg/m2 28 days × 2 ①②③
Wu J 2013 38/5 57 22/21 III–IV ≥3 ≥70 AD 10 mL + DOC 75 mg/m2 + DDP 100 mg/m2 DOC 75 mg/m2 + DDP 100 mg/m2 14 days × 3 ③
Sun NJ 2016 45/25 46.5 35/35 NR NR NR AD 50 mL + DDP 30 mg/m2 + 5-FU 500 mg/m2 DDP 30 mg/m2 + 5-FU 500 mg/m2 28 days × 2 ①③
Lu S 2009 62/58 50.9 60/60 II–III NR >60 SF 50 mL + NVB 25–30 mg/m2 + l-OHP 85 mg/m2 NVB 25–30 mg/m2+ l-OHP 85 mg/m2 8 days ②③
Zhang SQ 2011 54/29 55 42/41 NR >3 ≥50 SQFZ 250 mL + DDP 25 mg/m2 + CF 200 mg/m2 + 5-FU 500–750 mg/m2 DDP 25 mg/m2 + CF 200 mg/m2 + 5-FU 500–750 mg/m2 21 days× 2 ②③
Xu M 2010 50/10 58 30/30 II–III >3 >70 SQFZ 250 mL + DDP 100 mg/m2 + 5-FU 1000 mg/m2 DDP 100 mg/m2 + 5-FU 1000 mg/m2 10 days × 2 ①②③
Zheng HY 2012 32/28 61 31/29 NR ≥3 ≥60 CKS 10–20 mL + DOC 175 mg/m2 + DDP 20 mg/m2 + 5-FU 750 mg/m2 DOC 175 mg/m2 + DDP 20 mg/m2 + 5-FU 750 mg/m2 28 days× 3 ①②③
Hou JX 2012 38/22 54.4 30/30 III–IV NR ≥60 CKS 15 mL + DDP 20 mg/m2 + 5-FU 500 mg/m2 DDP 20 mg/m2 + 5-FU 500 mg/m2 21 days × 2 ①②③
Zhu LN 2011 48/30 50.5 42/36 NR >3 >60 CKS 30 mL + PTX 150 mg/m2 + NED 75 mg/m2 PTX 150 mg/m2 + NED 75 mg/m2 21 days × 2 ①②③
Su HT 2010 41/29 62.8 36/34 NR NR NR CKS 20 mL + DDP 15 mg/m2 + 5-FU 750 mg/m2 DDP 15 mg/m2 + 5-FU 750 mg/m2 21 days × 4 ①
Gao QH 2008 24/11 62 20/15 I–III NR NR CKS 20 mL + DDP 25 mg/m2 + 5-FU 500 mg/m2 DDP 25 mg/m2 + 5-FU 500 mg/m2 30 days × 2–5 ①②
Li EX 2002 NR 60 30/27 II–IV NR 50–80 CKS 20 mL + DDP 20 mg/m2 + 5-FU 500 mg/m2 DDP 20 mg/m2 + 5-FU 500 mg/m2 21 days × 2 ①②
Chen XY 2004 NR 35-76 37/30 III–IV NR NR CKS 20 mL + DDP 30 mg/m2 + 5-FU 300 mg/m2 DDP 30 mg/m2 + 5-FU 300 mg/m2 21–28 days × 2 ①③
Zhang GQ 2006 37/21 35-71 29/29 NR NR ≥60 HCS 30 mL + CF 100 mg/m2 + 5-FU 750 mg/m2 + DDP 20 mg/m2 CF 100 mg/m2 + 5-FU 750 mg/m2 + DDP 20 mg/m2 21 days × 2 ①②
Liu DG 2007 NR 53 30/30 NR NR ≥40 HCS 20 mL + OPT 7 mg/m2 + XF 200 mg/m2 + CTX 600 mg/m2 OPT 7 mg/m2 + XF 200 mg/m2 + CTX 600 mg/m2 15 days ①④
Liu HM 2011 48/22 61.1 35/35 III–IV NR NR HCS 20 mL + NVB 50 mg/m2 + DDP 80–100 mg/m2 NVB 50 mg/m2 + DDP 80–100 mg/m2 21 days × 2 ①
Han ZY 2012 85/43 NR 68/60 IV >3 ≥60 HCS 20 mL + 5-FU 250 mg/m2 + DDP 60 mg/m2 5-FU 250 mg/m2 + DDP 60 mg/m2 21 days × 2 ①②③
Xu JC 2008 NR NR 60/60 NR NR NR HCS 20–30 mL + DDP 20–30 mg/m2 + CF 200 mg/m2 + 5-FU 0.5–0.75 g/m2 DDP 20–30 mg/m2 + CF 200 mg/m2 + 5-FU 0.5–0.75 g/m2 15 days × 3 ①
Bai XH 2002 19/5 52 15/9. NR NR 72.5 KLT 200 mL + CF 200 mg/m2 + 5-FU 500 mg/m2 + DDP 20 mg/m2 CF 200 mg/m2 + 5-FU 500 mg/m2 + DDP 20 mg/m2 21 days × 3 ①
Li XY 1999 75/20 57.1 44/51 NR >3 >60 KLT 200 mL + DDP 40 mg/m2 + 5-FU 500–700 mg/m2 DDP 40 mg/m2 + 5-FU 500-700 mg/m2 28 days ①
Wang XQ 2016 32/20 55.4 26/26 NR NR NR EL 400–500 mg + PTX 135 mg/m2 + DDP 75–80 mg/m2 PTX 135 mg/m2 + DDP 75–80 mg/m2 21 days × 2 ①③
Lin Q 2013 37/13 55.9 30/30 III–IV >3 NR XAP 60 mL + l-OHP 85 mg/m2 + CF 400 mg/m2 + 5-FU 400 mg/m2 l-OHP 85 mg/m2 + CF 400 mg/m2 + 5-FU 400 mg/m2 7 days × 4 ①②③
Li HF2015 65/35 NR 50/50 >3 NR XAP 60 mL + DDP 30 mg/m2 + 5-FU 500 mg/m2 DDP 30 mg/m2 + 5-FU 500 mg/m2 21 days × 3 ①
Wang XJ 2015 35/27 56.6 31/31 III–IV >3 ≥60 XAP 40 mL + PTX 135 mg/m2 + DDP 25 mg/m2 PTX 135 mg/m2 + DDP 25 mg/m2 21 days × 2 ①
Li K 2007 19/11 67.2 15/15 NR ≥3 ≥50 XAP 60 mL + 5-FU 500 mg/m2 + DDP 30 mg/m2 5-FU 500 mg/m2 + DDP 30 mg/m2 21 days × 3 ①③
Yang J 2013 27/5 28/72 16/16 NR NR 40–90 XAP 40 mL + 5-FU 0.1 g/m2 + DDP 80–100 mg/m2 + ADM 80 mg/m2/ MMC 12 mg/m2 5-FU 0.1 g/m2 + DDP 80–100 mg/m2 + ADM 80 mg/m2/ MMC 12 mg/m2 28 days × 2–3 ①②③

NR, not reported. ① Clinical efficacy rate; ② performance status; ③ adverse reaction. AD, Aidi injection; SF, Shenfu injection; SQFZ, Shenqi Fuzheng injection; KLT, Kanglaite injection; EL, elemene injection; XAP, Xiaoaiping injection; CKS, Compound Kushen injection; HCS, Huachansu injection.