Table 2. Final Time-to-Death Model for Developmental Cohort Following Backward Eliminationa.
| Variable | HR (95% CI) | |
|---|---|---|
| Year 0 | Year 4 | |
| Age at index date, centered | 1.03 (1.03-1.03) | 1.03 (1.03-1.04) |
| Female | 0.87 (0.85-0.89) | 0.82 (0.78-0.87) |
| Cancer typeb | ||
| Lung | 1 [Reference] | 1 [Reference] |
| Breast | 0.33 (0.31-0.34) | 0.54 (0.49-0.60) |
| Colorectal | 0.51 (0.50-0.53) | 0.73 (0.66-0.81) |
| Prostate | 0.20 (0.19-0.21) | 0.45 (0.41-0.51) |
| Cancer stageb | ||
| I | 1 [Reference] | 1[Reference] |
| II | 1.64 (1.57-1.70) | 1.17 (1.08-1.26) |
| III | 2.70 (2.61-2.80) | 1.45 (1.34-1.58) |
| IV | 5.05 (4.87-5.23) | 1.98 (1.80-2.17) |
| Admitted to hospital in past 3 mo | 1.17 (1.14-1.20) | 1.94 (1.83-2.07) |
| Chronic disease | ||
| CHF | 1.21 (1.17-1.25) | 1.41 (1.32-1.51) |
| COPD | 1.19 (1.16-1.22) | 1.38 (1.29-1.47) |
| Dementia | 1.17 (1.11-1.23) | 1.63 (1.48-1.79) |
| Radiation in past 3 mo | 1.12 (1.09-1.14) | 1.48 (1.36-1.60) |
| Chemotherapy in past 3 mo | 1.06 (1.04-1.08) | 2.18 (2.03-2.33) |
| Surgery for cancer in past 3 mo | 0.77 (0.75-0.78) | NA |
| Distance from cancer center ≤50 km | 0.92 (0.90-0.93) | 0.94 (0.89-0.99) |
| Pain score | ||
| High | 1.14 (1.10-1.18) | 1.01 (0.90-1.13) |
| Moderate | 1.10 (1.07-1.13) | 0.96 (0.87-1.05) |
| Low | 1.04 (1.02-1.07) | 1.13 (1.04-1.23) |
| None | 1 [Reference] | 1 [Reference] |
| Well-being score | ||
| High | 1.15 (1.10-1.19) | 1.23 (1.09-1.39) |
| Moderate | 1.09 (1.05-1.13) | 1.10 (0.99-1.21) |
| Low | 1.05 (1.02-1.09) | 1.01 (0.93-1.10) |
| None | 1 [Reference] | 1 [Reference] |
| Functional scorec | ||
| 10-30 | 1.31 (1.23-1.39) | 1.19 (1.01-1.40) |
| 40-50 | 1.30 (1.25-1.35) | 1.30 (1.15-1.46) |
| 60-70 | 1.15 (1.11-1.19) | 1.41 (1.27-1.56) |
| 80-90 | 1.08 (1.05-1.11) | 1.35 (1.24-1.47) |
| 100 | 1 [Reference] | 1 [Reference] |
| Appetite | ||
| High, worst appetite | 1.36 (1.31-1.41) | 1.24 (1.08-1.42) |
| Moderate | 1.22 (1.18-1.26) | 1.30 (1.17-1.44) |
| Low | 1.14 (1.11-1.18) | 1.16 (1.05-1.27) |
| No problems, best appetite | 1 [Reference] | 1 [Reference] |
| Received home care | 1.43 (1.39-1.47) | 2.04 (1.87-2.23) |
| Hospitalized for palliative care | 8.00 (7.75-8.26) | 17.25 (15.66-19.00) |
| Resides in long-term care facility | 1.58 (1.50-1.67) | 1.78 (1.61-1.96) |
Abbreviations: CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; HR, hazard ratio; NA, not applicable.
a
A full list of covariates for each model is given in eTable 2 in the Supplement.
b
The HR estimates are from the main effects–only model (without the interaction between cancer type and cancer stage).
c
Functional score ranges from 0 to 100 (in 10-point increments), with 80 to 100 indicating stable, 40 to 70 indicating transitional, 10 to 30 indicating end of life, and 0 indicating dead.