Table 2.
Antiviral activity against CCR5-tropic HIV-1 in fresh human monocytes/macrophages.
| HIV-1 subtype B virus isolate (CCR5) | Mean EC50 |
||||
|---|---|---|---|---|---|
| AZT (nM) | MDH-1-38 (μM) | TI | NS1040 (μM) | TI | |
| BaL | 0.8 | 18.6 | 108 | 18.7 | 80.2 |
| 92BR017 | 0.7 | 1.04 | 1923 | 0.76 | 1974 |
| 92BR021 | 0.6 | 5.32 | 376 | 5.92 | 253 |
| 92TH026 | 0.6 | 11.0 | 182 | 0.66 | 2273 |
| 91US005 | <0.3 | 2.50 | 800 | 0.60 | 2500 |
| 92US660 | 0.7 | 4.97 | 402 | 1.59 | 943 |
| ADA | 2.0 | 15.7 | 127 | 20.1 | 74.6 |
Therapeutic index (TI) calculated from CC50 value of 2000 μM for MDH-1-38 and 1500 μM for NS1040 in fresh human monocyte/macrophages.