Table 1: Differential Diagnoses of Spontaneous Coronary Artery Dissection.

	Similarities	Differences
Atherosclerotic acute coronary syndrome	Clinical presentation Angiographic appearance in type 3 spontaneous coronary artery dissection lesions Acute and chronic recanalised atherosclerotic thrombus may mimic type 1 double lumen spontaneous coronary artery dissection	Male sex predominance Older patients than spontaneous coronary artery dissection High prevalence of cardiovascular risk factors No known association with fibromuscular dysplasia Less coronary tortuosity
Takotsubo cardiomyopathy	Clinical presentation Female sex predominance Frequently preceded by psychosocial/emotional stress Predominance of the theoretical left anterior descending coronary artery territory	Older patients than spontaneous coronary artery dissection No diagnostic findings on coronary angiogram/intracoronary imaging
Coronary embolism	Predominance of distal coronary segments Late angiographic healing	Presence of high-risk conditions of systemic embolism: atrial fibrillation, prosthetic heart valves, dilated cardiomyopathy with apical thrombus, infective endocarditis, myxoma or hypercoagulable state
Coronary spasm	Sometimes multifocal/multi-vessel involvement	Differences in clinical profile (typically angina at rest, during the night) Male sex predominance