ORF1 |
Non-structural proteins |
|
|
Methyltransferase |
Guanyltransferase, guanine-7-methyltransferase |
No |
Magden et al. (2001) |
Papain-like cystein protease |
Proteolytic processing of ORF1? Deubiquitinating activity |
No |
Karpe and Lole (2011), Parvez, 2013, Perttilä et al., 2013 and Sehgal et al. (2006)
|
Hypervariable region |
Influences efficiency of viral RNA replication, host/cell type specificity? |
No |
Pudupakam et al. (2011) and Shukla et al. (2012)
|
Macrodomain |
Poly-ADP-ribose-binding, weak ADP-ribose 1″-phosphohydrolase activity |
No |
Egloff et al. (2006) |
Helicase |
5′–3′ RNA unwinding, NTPase, RNA 5′-triphosphatase |
No |
Karpe and Lole, 2010a, Karpe and Lole, 2010b
|
RdRp |
RNA-dependent RNA polymerase activity |
No |
Agrawal et al. (2001) and Rehman et al. (2008)
|
|
ORF2 |
Capsid protein |
Yes (HEV-like particle) |
Guu et al. (2009) and Yamashita et al. (2009)
|
|
ORF3 |
Interaction with multiple cellular proteins, including Tsg101, hemopexin,…Suppression of interferon-α signalingParticle egress |
No |
Geng et al., 2013, Ratra et al., 2008, Surjit et al., 2006, Dong et al. (2012) and Yamada et al. (2009)
|