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DUB activity analysis of coronaviral PLproand PL2pro. (A) Relative DUB activities of MERS-CoV PLpro (0.17 μM), SARS-CoV PLpro (0.17 μM) and PEDV PL2pro (0.004 μM). Inhibition of PEDV PL2pro by 10–50 mM EDTA or 50 μM Zn2+ were also measured. Activity data of each set was normalized to that of PEDV PL2pro.
