Table 2.

Properties of monoclonal antibodies against MERS-CoV.

Source	Ab	Binding affinity (Kd, nM)	IC50 (μg/ml)		Efficacy	Reference
			Pseudotyped virus	Live virus
Mouse hybridoma	4C2	162	∼0.71	6.25	ND	(Li et al., 2015)
	2E6	60.3	∼0.29	1.56	ND
Humanized	4C2h	217	∼1.8	6.25	100% protection of Ad5-hCD26-transduced mice against virus infection
Humanized mice	REGN3051	0.0433	0.0098	0.069	100% protection hCD26 mice from virus infection	(Pascal et al., 2015)
	REGN3048	0.0485	0.011	0.027
Phage-display (Fab)	m336	4.27	0.005	0.07	100% survival in rabbits when administered before challenge; no protection observed when given after challenge	(Houser et al., 2016; Ying et al., 2014)

Kd, the equilibrium dissociation constant; IC₅₀, 50% inhibitory concentration.