Table 3.

Antivirals against chikungunya virus with unidentified targets and mechanism of action.

Antiviral agent	In vitro efficacy	In vivo efficacy	References
Trigocherrierin A	Inhibition of CHIKV-induced CPE in Vero A cells (EC50 = 0.6 μM)	Not determined	Bourjot et al. (2014)
Aplysiatoxin	Inhibition of CHIKV replication SJCRH30 cells (EC50 of the best compound = 1.3 μM)	Not determined	Gupta et al. (2014)
5,7-Dihydroxyflavones	Inhibition of CHIKV replication in both a BHK replicon cell line (Rluc EC50 = 28–60 μM) and infectious virus-based assays	Not determined	Pohjala et al. (2011)
[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones	Inhibition of CHIKV-induced CPE in Vero A cells (EC50 of the best compound <1 μM)	Not determined	Gigante et al. (2014)
Benzouracil–coumarin–arene conjugates	Inhibition of CHIKV-induced CPE in Vero A cells (EC50 = 10.2–19.1 μM)	Not determined	Hwu et al. (2015)