Fig. 2.

Reduction of influenza viral titers in the culture supernatants by the antiviral dihydrofuropyridinones. PR8-infected MDCK cells were incubated with different concentrations of 15a, 15g, 15q, or T-705 for 24 h. The supernatants were used for plaque titration (A) or for viral RNA quantification by quantitative RT-PCR (B). These experiments were performed twice in triplicate. P values were calculated against mock-treated, virus-infected samples. ^∗P < 0.05; ^∗∗P < 0.01. n.d., not detected.