Table 3.

SARS-CoV ORF6.

SARS-CoV p6
•Subcellular localization: ER and Golgi •Minor structural protein •Not required for SARS-CoV replication, but contribute to virulence
Domains and/or regions with characterized functions ■Amphipathic N-terminal (aa 2–37): induces membrane rearrangement and the formation of double membrane vesicles ■C-terminal (aa 54–63): critical for KPNA2 binding and inhibition of STAT1 nuclear import in response to interferon signaling ■Entire p6 protein: stimulates DNA synthesis ■Entire p6 protein: suppresses the expression of co-transfected plasmids