Table 1.
CC50, EC50, and SI value of Cationic Amphiphilic Drugs and Cholesterol Biosynthesis Inhibitor.
| Compounds | CC50 (μM) | FCoV-I KU2 |
FCoV-II 79-1146 |
||
|---|---|---|---|---|---|
| EC50 (μM) | SI | EC50 (μM) | SI | ||
| U18666A | 97.6 ± 3.7 | 0.2 ± 0.1 | 488.0 | >50.0 | <2.0 |
| AY-9944 | 66.7 ± 4.3 | 4.3 ± 0.1 | 15.4 | >50.0 | <1.3 |
| Clomiphene | 46.6 ± 10.8 | 3.7 ± 5.3 | 12.6 | 26.1 ± 8.9 | 1.8 |
| Ro 48-8071 | 248.7 ± 22.1 | 5.1 ± 0.4 | 48.8 | >100.0 | <2.5 |
| Amorolfine | 28.0 ± 3.5 | 13.7 ± 1.9 | 2.0 | 31.1 ± 2.2 | 0.9 |
| Fluvastatin | 74.4 ± 3.1 | 15.8 ± 2.2 | 4.7 | >50.0 | <1.5 |
| Lovastatin | 24.3 ± 1.9 | 25.9 ± 3.2 | 0.9 | >50.0 | <0.5 |
| Simvastatin | 9.6 ± 0.8 | 24.8 ± 0.3 | 0.4 | >50.0 | <0.2 |
| Alendronate | 153.3 ± 16.5 | 279.0 ± 33.4 | 0.5 | >100.0 | <1.5 |
| Itraconazol | 121.0 ± 5.0 | 0.7 ± 0.1 | 172.9 | 33.6 ± 3.6 | 3.6 |
Data are mean ± standard deviation.