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. 2020 Apr 3;38(16):3201–3209. doi: 10.1016/j.vaccine.2020.03.001

Table 2.

Comparison of SBA results for NadA antigen.

This study (HBcS-NadA) Comanducci et al. 2002 Comanducci et al. 2004
Dose (nmol) 0.82 0.89 0.89
No. of Doses 3 3 3
Adjuvant None CFA1 Alum or CFA
Mouse Strain NIH/OlaHsd, BALB/c CD1 CD1
Bacterial Strains NIBSC 2783 (92001) 2996, C11, F6124, MC58 2996, 65/96
Complement Source Baby Rabbit Serum Baby Rabbit Serum Baby Rabbit Serum
Median NadA Titre2 3072 12,288 12,288
Lowest Reported Titre 1024 4096 2048
Highest Reported Titre 4096 32,768 32,768
Median Control Titre 2 4 80
1

CFA = complete Freund’s adjuvant.

2

All studies use the NadA3 allele. Both Comanducci et al. studies used various bacterial strains for SBA analysis [42], [43]; however, only those SBA titres from strains expressing the NadA3 allele are included here.