Figure 4.

ROC curves of the four transcriptional signatures with the highest diagnostic accuracy benchmarked against WHO target product profile criteria

(A) Blue shaded areas represent the 95% CIs of the ROC curve sensitivities, plotted at 1% specificity intervals. AUROC values are reported with 95% CIs in brackets. (B) ROC curves are replicated with restricted y axes, and benchmarked against target criteria for a tuberculosis triage test. Minimum criteria (90% sensitivity, 70% specificity) are indicated by the dashed black boxes, optimum criteria (95% sensitivity, 80% specificity) are indicated by the blue boxes. Light blue shaded areas represent the 95% CIs. (C) ROC curves are replicated with restricted x axes and benchmarked against minimum criteria for a confirmatory test (dashed black box: 65% sensitivity, 98% specificity). Light blue shaded areas represent the 95% CIs. ROC=receiver operating characteristic. AUROC=area under the ROC curve.