Figure 5.

Tuberculosis scores of the four transcriptional signatures with the highest diagnostic accuracy in patients with Ultra-positive results

Patients with Ultra-positive results were grouped as true-positive tuberculosis (culture-positive or Xpert-positive) and false-positive non-tuberculosis (culture-negative or Xpert-negative). (A) Pie charts representing the proportion of Ultra-positive patients with tuberculosis and individuals without tuberculosis with a history of previous tuberculosis disease. (B) Scores of the four transcriptional signatures with the highest diagnostic accuracy in patients with Ultra-positive results. Red dots indicate patients for whom only traces of Mycobacterium tuberculosis were detected by Ultra analysis. Dashed lines represent the score thresholds of the maximum Youden index, identified from analysis of all patients. The score difference between patients with and without tuberculosis was significant for all four signatures (Mann-Whitney test p<0·0001).