Table 4.

Sensitivity and specificity of a diagnostic algorithm combining the sputum Ultra test with blood transcriptional signature analysis

	Ultra test alone	Addition of signature to:
		All Ultra-positive individuals	Ultra trace-positive individuals	Ultra-positive individuals with previous tuberculosis
Sensitivity
BATF2	82% (69–90)	76% (63–86)	82% (69–90)	80% (67–89)
Kaforou25	..	66% (52–78); p=0·013	82% (69–90)	74% (60–84)
Roe3	..	78% (65–87)	82% (69–90)	80% (67–89)
Sweeney3	..	76% (63–86)	80% (67–89)	78% (65–87)
Specificity
BATF2	90% (83–95)	99% (95–100); p=0·0077	95% (89–98)	96% (91–98); p=0·041
Kaforou25	..	100% (96–100); p=0·0044	96% (91–98); p=0·041	97% (92–99); p=0·023
Roe3	..	99% (95–100); p=0·0077	95% (89–98)	96% (91–98); p=0·041
Sweeney3	..	100% (96–100); p=0·0044	96% (91–98); p=0·041	97% (92–99); p=0·023

Data are % (95% CI). Only significant p values are shown. Sensitivity and specificity were calculated for 154 patients with Ultra results, with or without reclassification of selected Ultra-positive tests by transcriptional signatures. p value of comparison with Ultra alone using McNemar's test.