Table 1.
IC50 and CC50 using Vero E6 and Huh7 cells and CCHFV strains 86–07 and 87–07.
| Vero E6 |
Huh7 |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CCHFV strain |
86–07 |
87–07 |
||||||||||
| Molecule | IC50 (μM) | p Value | CC50 (μM) | SI | IC50 (μM) | p Value | CC50 (μM) | SI | IC50 (μM) | p Value | CC50 (μM) | SI |
| Chloroquine | 39.4 (±0.031) | 1000 | 26.9 | 28.1 (±0.042) | nsa | 1000 | 35.6 | 43.4 | nsb | 926 | 21.3 | |
| Chlorpromazine | 10.6 (±0.031) | 30 | 2.8 | 15.8 (±0.051) | nsa | 30 | 1.9 | 4.3 | ⁎⁎,b | 30 | 7.1 | |
IC50: Inhibitory concentration (μM).
Cell viability was assayed at 1 d p.i.
SI: Selectivity index, CC50/IC50.
p Value: ns: non significative, ⁎: p < 0.05, ⁎⁎: p < 0.005.
a
86.07 compared to 87–07.
b
Vero E6 compared to Huh7.