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. 2018 Jun 18;156:92–101. doi: 10.1016/j.antiviral.2018.06.011

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© 2018 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 3 — Rac1, the drug target of 6-TG, sustains rotavirus replication. (A) Western blot assay detected Rac1 in transduced Caco2 cells transduced lentiviral RNAi vectors against Rac1 (The ratio of Rac1/β-actin was expressed in arbitrary units). (B) Three (No. 9687, 9689 and 9690) out of five lentiviral shRNA vectors inhibited rotavirus genomic RNA (n = 6–10, means ± SEM, *P < 0.05, ***P < 0.001, Mann-Whitney test). (C) Western blot assay confirmed knockout of Rac1 in Rac1 knockout (−/−) MEF cells. (D) SA11 rotavirus replication was significantly attenuated in Rac1 knockout (−/−) MEF cells (n = 4, means ± SEM, *P < 0.05, Mann-Whitney test).