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. 2018 Jun 18;156:92–101. doi: 10.1016/j.antiviral.2018.06.011

Fig. 5.

Fig. 5

6-TG inhibits rotavirus via suppression of Rac1 activation. (A) Anti-rotavirus effect of 6-TG (100 ng/mL) was attenuated in Rac1 knockdown Caco2 cells (The ratio of VP4/β-actin was expressed in arbitrary units). (B) 6-TG inhibited GTP-Rac1 detected by pull-down assay. (C) Anti-rotavirus effect of NSC23766 (25 μg ng/mL) was attenuated in Rac1 knockdown Caco2 cells. (D) The anti-rotavirus effect of 6-TG (100 ng/mL) was attenuated in Rac1 knockout (−/−) MEF cells (n = 6–8, means ± SEM, *P < 0.05, **P < 0.01, Mann-Whitney test).