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. 2017 Sep 19;146:191–200. doi: 10.1016/j.antiviral.2017.09.010

Fig. 4.

Fig. 4

Celastrol increases IFN-mediated antiviral genes expression. (A) Celastrol stimulates ISRE activity. Ava5 cells were transfected with 0.5 μg of pISRE-Luc followed by 0, 0.2, or 0.5 μM of celastrol and incubated for 3 days. Luciferase activity represented ISRE activity. (B) Celastrol stimulates the expression level of antiviral genes. Ava5 cells were treated with 0, 0.2, or 0.5 μM of celastrol for 3 days, and RNA levels of OAS1, OAS2 and OAS3 were analyzed by qRT-PCR. Error bars denote the mean ± SD of three independent experiments. *P < 0.05.