Table 1.

Celastrol synergistically or additively inhibits HCV replication when combined with IFN-α, sofosbuvir, daclatasvir or telaprevir. Standard deviations denote the mean ± SD of three independent experiments.

Combination compound	Combination index values at
	EC50	EC75	EC90
IFN-α	1.01 ± 0.02	0.93 ± 0.04	0.86 ± 0.01
Sofosbuvir	0.31 ± 0.05	0.44 ± 0.02	0.63 ± 0.01
Daclatasvir	0.40 ± 0.06	0.43 ± 0.07	0.46 ± 0.02
Telaprevir	1.03 ± 0.04	0.99 ± 0.08	0.97 ± 0.03