Table 1.

Viruses against which ARB has demonstrated antiviral activity. Virion type: E, enveloped; NE, non-enveloped. References in bold report animal studies of ARB antiviral activity. See text for details and abbreviations.

Family	Virus	Virion type	In vitro IC50 (μM)	In vivo (mg/kg/day)	DAA/HTA	References
Orthomyxoviridae	Influenza	E	2.5–16	A/H3N2 2–50	Both	Brooks et al., 2012, Fediakina et al., 2005, Fediakina et al., 2011, Leneva and Shuster, 2006, Leneva et al., 2010, Liu et al., 2013b, Loginova et al., 2008, Shi et al., 2007
			A/H3N2 12	A/H1N1 100
			B 13.3	A/H1N1 90–180
				A 15–30
Paramyxoviridae	RSV	E	16	–	nd/HTA	Shi et al. (2007)
			no IC50	10–50	nd/HTA	Brooks et al. (2012)
Picornaviridae	Poliovirus 1	NE	0.41	–	nd/HTA	Brooks et al. (2012)
	Rhinovirus 14	NE	12.2	–	nd/HTA	idem
	Coxsackie B5	NE	5	50	Both	Zhong et al. (2009)
Bunyaviridae	Hantaan	E	2	5–20	Both	Deng et al., 2009, Wei et al., 2013
Rhabdoviridae	VSV	E	14	–	nd/HTA	Blaising et al. (2013)
Reoviridae	Reovirus T1L	NE	10	–	nd/HTA	Blaising et al. (2013)
Togaviridae	Chikungunya	E	12.2	–	not DAA/HTA	Delogu et al. (2011)
Hepadnaviridae	HBV	E	DNA replic 43 HBsAg 90	–	nd/HTA	Zhao et al. (2006)
Flaviviridae	HCV	E	2–11.3	–	Both	Blaising et al., 2013, Boriskin et al., 2006, Boriskin et al., 2008, Haid et al., 2009, Pécheur et al., 2007, Teissier et al., 2011