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. 2016 Dec 9;139:1–12. doi: 10.1016/j.antiviral.2016.12.007

Fig. 2.

Fig. 2

Effects of various long-term dosing regimens of Hiltonol® on neutralizing antibody titers of BALB/c mice at day 7 (A) and 14 (B) post virus challenge with a lethal dose of SARS-CoV. **p < 0.01 versus PSS (day −14), ***p < 0.001 versus Hiltonol® 2.5 mg/kg (day −14) or Hiltonol® 0.75 mg/kg (day −7). The SARS-CoV-infected BALB/c mice were treated with PSS (●: day −21), (○: day −14), (◇: day −7); Hiltonol® (■: 2.5 mg/kg/day −21), (□: 2.5 mg/kg/day −14), (▼: 2.5 mg/kg/day −7); (▲: 0.75 mg/kg/day −21), (▽: 0.75 mg/kg/day −14), (△: 0.75 mg/kg/day −7), (♦) Ampligen® 10 mg/kg/day (bid x 2 beg, 4 h).