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. 2016 Dec 9;139:1–12. doi: 10.1016/j.antiviral.2016.12.007

Table 1.

Effects of various dosing regimens of Hiltonol® on a lethal SARS-CoV infection in a BALB/c mouse model.

Treatments Live/total Mean day of death ± SD Weight loss from day 0 to day 3 (g) Average weight through day 18 (g) ± SD
PSS (−24, +24, +48 h) 0/10 4.2 ± 1.2*** 2.5 15.9 ± 2.7
Hiltonol® 5 mg/kg/day (−24, +24, +48 h) 10/10 >18 0.4 17.8 ± 0.5***
Hiltonol® 5 mg/kg/day (−24, +8, +24 h) 10/10 >18 0.7 17.7 ± 0.5***
Hiltonol® 5 mg/kg/day (−16, +8, +32 h) 10/10 >18 1.0 17.9 ± 0.7***
Hiltonol® 5 mg/kg/day (−24 h) 9/10 4 2.7 16.7 ± 1.13*
Hiltonol® 5 mg/kg/day (+12 h) 9/10 4 0.7 18.2 ± 0.5***
Hiltonol® 1 mg/kg/day (−24, +24, +48 h) 9/10 11 1.1 17.4 ± 0.5*
Hiltonol® 1 mg/kg/day (−24, +8, +24 h) 10/10 >18 0.1 17.3 ± 0.6*
Hiltonol® 1 mg/kg/day (−16, +8, +32 h) 10/10 >18 0.5 17.3 ± 0.8*
Hiltonol® 1 mg/kg/day (−24 h) 10/10 >18 0.3 18.4 ± 0.2***
Hiltonol® 0.5 mg/kg/day (−24, +24, +48 h) 10/10 >18 0.2 17.6 ± 0.3*
Hiltonol® 0.5 mg/kg/day (−24, +8, +24 h) 10/10 >18 0.4 17.2 ± 0.3*
Hiltonol® 0.5 mg/kg/day (−16, +8, +32 h) 10/10 >18 0.3 17.3 ± 0.5*
Hiltonol® 0.25 mg/kg/day (−24, +24, +48 h) 10/10 >18 0.2 17.6 ± 0.4**
Hiltonol® 0.25 mg/kg/day (−24, +8, +24 h) 10/10 >18 0.0 17.5 ± 0.4**
Hiltonol® 0.25 mg/kg/day (−16, +8, +32 h) 10/10 >18 0.0 18.0 ± 0.4***

*p < 0.05, **p < 0.01, ***p < 0.001.