Table 4.
Effects of various long-term dosing regimens of Hiltonol® on death of BALB/c mice infected with a lethal dose of SARS-CoV post virus exposure.
Treatment | Dosing regimen (hour post virus exposure) | Live/total | Mean day of death |
---|---|---|---|
PSS | −24, + 24, +48, 72 h | 1/10 | 6.0 |
Hiltonol® (5 mg/kg/day) | +8 h | 9/10*** | Undefined |
Hiltonol® (5 mg/kg/day) | +16 h | 4/10 | 6.5 |
Hiltonol® (5 mg/kg/day) | +24 h | 3/10 | 6.0 |
Hiltonol® (5 mg/kg/day) | +32 h | 1/10 | 4.0 |
Hiltonol® (5 mg/kg/day) | +48 h | 0/10 | 5.0 |
Hiltonol® (5 mg/kg/day) | +72 h | 0/10 | 6.0 |
Hiltonol® (5 mg/kg/day) | +8, + 24 h | 10/10*** | Undefined |
Hiltonol® (5 mg/kg/day) | −24, +8, +32 h | 10/10*** | Undefined |
***p < 0.001 versus PSS control.