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Effects of Hiltonol® on the death of C57BL/6J and B6.129S2-IL6m1kopf/J mice infected with a lethal dose of mouse-adapted SARS-CoV.
| Treatment | Dosing regimen (hour post virus exposure) | Live/total | Mean day of death |
|---|---|---|---|
| PSS C57BL/6J | −24, +8, +32 h | 8/20 | 4.8 ± 2.3 |
| Hiltonol® C57BL/6J | −24, +8, +32 h | 7/20 | 4.6 ± 2.2 |
| PSS B6.129S2-IL6tm1Kopf/J | −24, +8, +32 h | 4/10 | 4.5 ± 2.3 |
| Hiltonol® B6.129S2-IL6tm1Kopf/J | −24, +8, +32 h | 4/10 | 4.8 ± 1.7 |
***p < 0.001 versus PSS control.
