Table 6.
Effects of Hiltonol® on various lung parameters measured in IL-6 knockout mice (IL-6 -/-) mice infected with mouse adapted SARS-CoV.
| Treatment | Virus titer (Log10 CCID50/g) ± SD | Visual lung score ± SD | Lung weight (g) ± SD |
|---|---|---|---|
| Day 3 | |||
| PSS C57BL/6J | 6.27 ± 0.07 | 0.0 ± 0.0 | 0.32 ± 0.35* |
| Hiltonol® (1 mg/kg/) C57BL/6J | 4.31 ± 0.09*** | 0.0 ± 0.0 | 0.12 ± 0.02 |
| PSS B6.129S2-IL6tm1Kopf/j | 6.75 ± 0.12 | 0.3 ± 0.3* | 0.06 ± 0.01 |
| Hiltonol® (1 mg/kg/) B6.129S2-IL6tm1Kopf/j | 5.02 ± 0.15*** | 0.0 ± 0.0 | 0.09 ± 0.02 |
| Day 6 | |||
| PSS C57BL/6J | 3.51 ± 0.09 | 0.0 ± 0.0 | 0.12 ± 0.05 |
| Hiltonol® (1 mg/kg/) C57BL/6J | 4.94 ± 0.02*** | 0.0 ± 0.0 | 0.12 ± 0.02 |
| PSS B6. 129S2-IL6tm1Kopf/j | 4.65 ± 0.12 | 0.3 ± 0.4 | 0.11 ± 0.01 |
| Hiltonol® (1 mg/kg/) B6.129S2-IL6tm1Kopf/j | 5.36 ± 0.00*** | 0.0 ± 0.0 | 0.09 ± 0.00 |
***p < 0.001 versus PSS control.