Table 1.
Screening results and IC50(HTRF) of selected compounds on the SARS-nsp14 by HTRF assay.
| Compounds | HTRF signal increase at 50 μM (%) | IC50(HTRF) (μM) |
|---|---|---|
| 152 | 51.4 | 171.5 ± 16 |
| 792 | 50 | 5.8 ± 2 |
| 210 | 42.5 | 17.1 ± 5.6 |
| 909 | 41 | >400 |
| 545 | 34.8 | >400 |
| 1159 | 33.9 | Not available |
| 602 | 33.3 | 73.6 ± 29 |
| 1426 | 32.7 | 0.16 ± 0.02 |
| 1040 | 30.8 | 5.5 ± 1 |
| 1298 | 29.4 | 2 ± 0.6 |
| 1305 | 29 | 3.3 ± 0.7 |
| 604 | 27.9 | 57.2 ± 15 |
| 597 | 26.8 | Not available |
| 1418 | 25.4 | 18.9 ± 3.8 |
| 925 | 25 | 5 ± 0.6 |
| 1207 | 22.8 | 73 ± 9.3 |
| 312 | 21.8 | 38.6 ± 5 |
| 194 | 21.8 | Not available |
| 752 | 21.5 | 35.5 ± 7.3 |
| 1434 | 20 | >400 |
| Sinefungin | 96.9 | 0.112 ± 0.01 |
Not available: IC50(HTRF) not accurate due to fluorescence issues at high compound concentrations.