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Comparison of the IC50 value of 11 most active compounds on SARS-nsp14 and human RNMT activities using GpppAUAU and GpppAC4 substrates respectively.
| Compounds | IC50 SARS-nsp14 (μM) | IC50 RNMT (μM) |
|---|---|---|
| Sinefungin | 0.36 ± 0.08 | <0.05 |
| 925 | 1.5 ± 0.11 | 1 ± 0.1 |
| 1426 | 0.019 | ND |
| 1298 | 0.74 ± 0.1 | 0.32 ± 0,27 |
| 1305 | 1.3 ± 0.2 | 0.4 ± 0.05 |
| 1040 | 4.5 ± 0.35 | 5.1 ± 2.28 |
| 792 | 31 ± 3 | 5.5 ± 1.92 |
| 1159 | 2 ± 0.44 | <0.05 |
| 312 | 12.3 ± 1 | 4.84 ± 1.6 |
| 1418 | 23.7 ± 7 | 10 ± 3 |
| 1207 | 18.4 ± 2 | ND |
| 604 | 11 ± 1 | 1.28 ± 0.16 |
ND: Not Determined.
