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Evaluation of compound 312 analogs. IC50 determined by FBA on SARS-CoV nsp14 and RNMT MTase activities using GpppAC4 substrate.
| Compounds | Structure | IC50 (μM) on |
|
|---|---|---|---|
| SARS nsp14 | RNMT | ||
| 312 |  |
7.3 ± 0.4 | 14.3 ± 1 |
| 457 |  |
6.2 ± 0.4 | 8.8 ± 0.6 |
| 278 |  |
9.1 ± 0.7 | 16.8 ± 2 |
| 1264 |  |
13.5 ± 2 | 13.7 ± 0.8 |
| 133 |  |
No inhibition | 365.2 ± 186 |
| 510 |  |
No inhibition | 159 ± 36 |
| 706 |  |
No inhibition | 226.8 ± 29 |
| 503 |  |
No inhibition | 102.2 ± 21 |
