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. 2018 Aug 4;158:88–102. doi: 10.1016/j.antiviral.2018.08.002

Fig. 5.

Fig. 5

Development of bifunctional molecules that specifically bind to a target viral protein and induce its degradation. A small molecule ligand for a specific viral target is conjugated to a ligand for cereblon (CRBN), an adapter of Cullin-Ring-Ligase (CLR) complexes. Figure kindly provided by Melissanne de Wispelaere.