Table 2.
Drug development pipeline of HBV core assembly modulators (CAMs).
| Name | Class (MoA) | Phase | Company |
|---|---|---|---|
| NVR 3-778 | I (AT130-like) | 2 | Novira, Janssen, USA/Belgium |
| GLS4 | II (HAP-like) | 2 | HEC Pharma, China |
| RO7049389 | II (HAP-like) | 1b done→ 2 | Hoffmann-La-Roche, Switzerland |
| JNJ-6379 | I (?) (AT130-like) | 1b done→ 2 | Janssen, Belgium/USA |
| ABI-H0731 | II (?) | 1b/2a | Assembly Biosciences, USA |
| AB-423 | (?) | 1b | Arbutus Biopharma, USA |
| EP-027367 | (?) | IND | Enanta Pharmaceuticals, USA |
| AB-506 | (?) | IND | Arbutus Biopharma, USA |
| ABI-H2158 | (?) | IND | Assembly Biosciences, USA |