Fig. 5.

m27f neutralizes HSV-1 and HSV-2 at the post-binding stage. Comparison of neutralization efficacy of m27f when serial dilutions of antibodies were added before (A and C, pre-attachment) or after (B and D, post-attachment) HSV virions interacted with Vero cells. 21C11 was used as a control. Neutralization efficacies were determined after 72 h as described above for the standard neutralization assay. The percent inhibition was determined relative to the negative control. Representative data (mean ± SEM) from at least 3 independent experiments performed are shown.